🌍 Global Infectious Diseases & One Health Conference

Presenter: Michele Mishto

Affiliation: King’s College London, United Kingdom

Presentation Type: Keynote Presentation (In-Person)

Title: Pathogen-derived noncanonical epitopes: are they valuable targets for novel vaccinations?

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🧬 Exploring Noncanonical Epitopes for Next-Generation Vaccines

Major Histocompatibility Complex (MHC) class I molecules present antigenic peptides derived not only from canonical proteins but also from sequences generated through post-translational mechanisms such as proteasome-generated peptide splicing.

These noncanonical epitopes represent a promising yet underexplored field in infectious disease immunology and vaccine development.

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🦠 Pathogen-Derived Spliced Peptides in Immune Response

Recent research has focused on identifying pathogen-derived noncanonical epitopes and evaluating their immunogenic potential. Advanced computational pipelines have been developed to:

🔬 Identify canonical pathogen epitopes
🧬 Predict noncanonical epitopes generated by peptide splicing
💉 Evaluate their immunogenicity in infectious diseases
⚕ Explore their therapeutic potential in vaccine development

These tools are expanding the possibilities for designing innovative vaccines against infectious diseases.

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⚠ Future Perspectives in Vaccine Research

Although pathogen-derived noncanonical epitopes offer promising opportunities, researchers must carefully evaluate the risk of autoimmune responses that could potentially be triggered by these peptides.

Understanding immune balance is crucial for developing safe and effective vaccines.

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👨‍⚕️ Biography

Prof. Michele Mishto is Professor in Immunobiology at King’s College London and Senior Group Leader at the Francis Crick Institute in London (UK).

He completed his PhD in Medical Biotechnology at the University of Bologna (Italy) and later conducted postdoctoral research at the Institute of Biochemistry at Universitätsmedizin Charité Berlin (Germany).

His research focuses on antigen presentation and proteasome biology, particularly the discovery and characterization of proteasome-generated spliced peptides and their role in immune responses in cancer and infectious diseases.

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🌍 Conference Details

📅 Dates: September 21–23
📍 Venue: London, United Kingdom & Online

🔗 Website: https://infection.miconferences.com/
📝 Register: https://infection.miconferences.com/register

📧 Email: infection@mathewsconference.com
📞 Phone: +1 (312) 462-4448
💬 WhatsApp: +1 (424) 377 0967

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